Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special - 40% off – Mayo Clinic Diet Online, bloating or swelling of the face, arms, hands, lower legs, or feet, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, sores, ulcers, or white spots on the lips or in the mouth, burning, dry, itching, or watering of the eyes, redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. Call your doctor for medical advice about side effects. All drugs may cause side effects. There are no contraindications listed in the manufacturer’s labeling. Free moxidectin can have an adverse effect on aquatic organisms, including fish. Advertising revenue supports our not-for-profit mission. Keep dogs from licking each other for two hours after the product is applied. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. • It is used to treat eye and skin disease caused by certain worms (O. volvulus). Those who took 36 mg with food had higher incidences of hema-tological adverse events, such as leukopenia, leukocytosis, eosinophilia, and monocytosis, than with placebo. This content does not have an English version. Moxidectin is being evaluated as a treatment to eradicate scabies in humans, specially when they are resistant to other treatments. These reactions generally occur and resolve in the first week post-treatment. When moxidectin contacts soil, it tightly and readily binds and is deactivated. If you notice any other effects, check with your healthcare professional. Available for Android and iOS devices. Safety and efficacy of repeat administration of moxidectin in patients with O. volvulus has not been studied. Some of the side-effects may be rare but serious. If you notice any of these side effects or have any concerns about your dog, please contact your veterinarian as soon as possible. Portions of this document last updated: Oct. 01, 2020. How Imidacloprid and Moxidectin is Supplied Advantage Multi® … Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%), Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%), Dermatologic: Pruritus (65%), skin rash (37%), Endocrine & metabolic: Hyponatremia (12%), Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%), Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymphocytopenia (48%: grade 3: 23%), leukocytosis (25%), neutropenia (20%: grade 4: 7%), Neuromuscular & skeletal: Musculoskeletal pain (64%), Respiratory: Flu-like symptoms (23%), cough (17%), Cardiovascular: Symptomatic orthostatic hypotension (5%), Endocrine & metabolic: Increased gamma-glutamyl transferase (3%), Hematologic & oncologic: Eosinopenia (5%), Hepatic: Hyperbilirubinemia (3%), increased serum alanine aminotransferase (1%), increased serum aspartate aminotransferase (1%), Ophthalmic: Eye pain (8%), eye pruritus (7%), visual impairment (3%; including blurred vision, low vision acuity), allergic conjunctivitis (2%), eyelid edema (2%), conjunctival hyperemia (≤2%), ocular hyperemia (≤2%), increased lacrimation (1%), Frequency not defined: Dermatologic: Mazzotti reaction. 3 DOSAGE FORMS AND STRENGTHS . All drugs may cause side effects. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). trouble seeing. Skin microfilarial counts; screening for loiasis prior to treatment in patients exposed to Loa loa-endemic areas; signs and symptoms of Mazzotti reaction, including symptomatic orthostatic hypotension. Diarrhea. Pharmacokinetics were dose-proportional and there was little or no systemic accumulation. This leads to increased permeability, influx of chloride ions, hyperpolarization, and muscle paralysis. 5.1 Cutaneous, Ophthalmological and/or Systemic Adverse Reactions Treatment with Moxidectin Tablets may cause cutaneous, ophthalmological and/or systemic reactions of varying severity (Mazzotti reaction). For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. feeling of having something in the eye. Note: This is not a comprehensive list of all side effects. Social media is buzzing about an Australian study on the possible antiviral effects that ivermectin might have on the COVID-19 virus. (And, in case you missed it … there’s 3 times as much moxidectin in ProHeart 12 as Proheart 6 … so side effects are likely to be greater.) • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. However, many people have no side effects or only have minor side effects. This results in moxidectin having a broader distribution into the tissues, with a significantly longer residual effect so that parasites are exposed to it for a longer time. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. There is a trend toward an increased incidence of these adverse reactions in patients with higher microfilarial burden. Mayo Clinic does not endorse companies or products. All patients have their different intensity of side effects. Moxidectin and other medications in the same drug class can be toxic to sensitive dogs, particularly herding breeds. Following intravenous (IV) dosing of a combination solution of sarolaner and moxidectin, the sarolaner volume of distribution (V ss ) was 2.4 L/kg and systemic clearance (CL) was 6.0 mL/kg/hr. Moxidectin, an anthelminthic agent, is active against the microfilariae of O. volvulus, but not effective in killing the adult worms. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Moxidectin has been approved by the FDA, but isn’t available in pharmacies yet.. Call your doctor or Moxidectin 3/7. Medically reviewed by Drugs.com. Onchocerciasis: Treatment of onchocerciasis due to Onchocerca volvulus in patients ≥12 years of age. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Once opened, administer within 24 hours. Cough. They are more frequent after subcutaneous injection than after spot-on administration. Has been approved by the product: Orthostatic hypotension: Orthostatic hypotension may,. And there was little or no systemic accumulation blood pressure was transient and managed by resuming recumbency a... 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