2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). In our systematic review of the epidemiology of UFs, we found wide variations in both the methodology and quality of the 60 selected studies, and also in the epidemiological data they report, with UF incidence ranging between 217 and 3745 cases per 100 000 women‐years and UF prevalence ranging between 4.5% and 68.6%. Role of Hormones in Common Benign Uterine Lesions: Endometrial Polyps, Leiomyomas, and Adenomyosis. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username. The UF risk factor with the strongest evidence is black race. Objectives: To examine UF epidemiology and to evaluate the relative strengths of putative risk factors. Their prevalence usually is estimated at 30-40%, but may reach up to 70-80% in predisposed groups of women. Uterine myomas: clinical impact and pathophysiological bases. Analyses of the Nurses’ Health Study II and the Black Women's Health Study showed that inclusion of pelvic examination as a diagnostic method in addition to ultrasound or hysterectomy can increase the reporting of UFs compared with ultrasound or hysterectomy alone (Figure 1A).44, 62. Oxytocin selectively reduces blood flow in uterine fibroids without an effect on myometrial blood flow: a dynamic contrast enhanced MRI evaluation. This evaluation reveals the important risk factors to be age, premenopausal state, hypertension, family history, time since last birth, and food additive and soybean milk consumption. 2011 Jun;20(6):915-22. doi: 10.1089/jwh.2009.1782. Black race and 11 other factors affect uterine fibroid risk. Topics ranged from molecular techniques for mapping uterine fibroid cells to the use of green tea extract as a potential treatment. For risk factors that were stratified by intervals (e.g. 2008 Aug;22(4):571-88. doi: 10.1016/j.bpobgyn.2008.04.002. Black race and 11 other factors affect uterine fibroid risk. Int J Trichology. COVID-19 is an emerging, rapidly evolving situation. Study and reporting quality was good in all the registry studies and most of the ‘other observational’ studies, but poorer in over two thirds of the single‐centre studies. 10–14 Black women experience fibroids at an earlier age, have more severe symptoms, 10,15 and increased disease burden 15,16; however, less is known about other minorities, including Hispanic women. Mehine M, Khamaiseh S, Ahvenainen T, Heikkinen T, Äyräväinen A, Pakarinen P, Härkki P, Pasanen A, Bützow R, Vahteristo P. Cancers (Basel). Feasibility of quantitative MR-perfusion imaging to monitor treatment response after uterine artery embolization (UAE) in symptomatic uterus fibroids. Journal of Minimally Invasive Gynecology. ing history. Comparing Perioperative Outcomes of Uterine Artery Embolization and Hysterectomy in Insurer and Demographically Diverse Populations: A Retrospective, Multi-Center Database Study. These benign tumors are hormone-dependent, develop after puberty and regress after menopause. Exposure to organophosphate esters, phthalates, and alternative plasticizers in association with uterine fibroids. 4 Both estrogen and … This finding was due, perhaps in part, to secular trends of decreasing hysterectomies. Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women. Data on UF incidence, prevalence and associated risk factors were extracted from 60 publications. Robot-Assisted Laparoscopic Myomectomy versus Abdominal Myomectomy for Large Myomas Sized over 10 cm or Weighing 250 g. Benign Primary Vaginal Leiomyoma- a diagnostic challenge: Rare case report. Objectives: Incidence increases with age during the reproductive years such that cases occur in 20% to 50% of women older than 30 years. Epub 2020 Sep 19. Nomogram to predict postpartum hemorrhage in cesarean delivery for women with scarred uterus: A retrospective cohort study in China. Incidence, aetiology and epidemiology of uterine fibroids. In a retrospective, single‐centre study of the ultrasound records of women in Israel experiencing UF symptoms, those aged 41–50 or 51–60 years were 10 times more likely to have UFs than those aged 21–30 years (Table 1).74 However, in a postmenopausal age group, i.e. Risk factors. Treatment of patients with uterine myoma in the period of menopausal transition. Development and Validation of Hormonal Impact of a Mouse Xenograft Model for Human Uterine Leiomyoma. Use the link below to share a full-text version of this article with your friends and colleagues. 3'RNA Sequencing Accurately Classifies Formalin-Fixed Paraffin-Embedded Uterine Leiomyomas. In total, over 30 broad categories of risk factor for UFs were examined across the studies (Table S2). Uterine fibroids are noncancerous growths of the uterus that often appear during childbearing years. Main results: 2020 Dec;61(12):1054-1059. doi: 10.3349/ymj.2020.61.12.1054. In a single‐centre study in Japan, the risk of UFs in women who had given birth three or more times was less than one‐fifth that of nulliparous women (Table 1).79, Use of both oral and injectable contraceptives has also been found to be associated with a reduced risk of developing UFs. High-quality prospective observational data are needed to improve our understanding of UF epidemiology, and thus its aetiology and optimal management. Learn more. 2020 Jul-Aug;12(4):176-181. doi: 10.4103/ijt.ijt_37_20. Black race was the only factor that was recurrently reported to increase UF risk, by two–threefold compared with white race. The epidemiology, diagnosis, and natural history of uterine leiomyomas are reviewed here. J Womens Health (Larchmt). Time since last birth was reported to increase UF risk in two registry studies.51, 60 In some analyses, however, this risk was not adjusted for age and may therefore be partly due to the effect of increasing age. Study quality and reporting quality were good in most (80%; 48/60) of the included publications, defined as fulfilling 19 or more of the 22 statements on the STROBE checklist (Table S3).45 This included all the registry studies and six of the seven ‘other observational’ studies, but less than one third (31%; 5/16) of the single‐centre studies. Reproductive status plays a notable role in UF development. Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. The reported incidences of UFs also ranged widely (217–3745 cases per 100 000 women‐years; Figure 1A).48, 66 Only one study reported solely on women with asymptomatic UFs,47 and at least one third of studies described mixed populations of women with symptomatic and asymptomatic UFs. If lower 95% CI ≥ 1.5 then included as a risk factor; if upper 95% CI ≤ 0.67 then included as a protective factor. Examining Disparities in Route of Surgery and Postoperative Complications in Black Race and Hysterectomy. Uterine Fibroids epidemiology: Find out the number of patients diagnosed (prevalence) with Uterine Fibroids by countries. We identified 12 risk factors that play an important role in UF epidemiology. Uterine Myomas: Focused Ultrasound Surgery. self‐report, pelvic examinations, ultrasound or surgery), comparator group definitions, risk measures (e.g. Much of the information available on UF prevalence came from single‐centre studies with populations that were not representative of the general population (e.g. Search strategy: NIH Mass spectrometry imaging: An emerging technology for the analysis of metabolites in insects. Metformin use is associated with a lower risk of uterine leiomyoma in female type 2 diabetes patients. Association of Race/Ethnicity with Surgical Route and Perioperative Outcomes of Hysterectomy for Leiomyomas. Almost all the included studies were subject to selection bias (Table S3). Oral contraceptive use was also found to reduce the risk of developing UFs. Our comprehensive literature searches used pre‐specified search terms to select the publications included in this review, to ensure that all relevant data on the epidemiology of symptomatic and asymptomatic UFs were extracted without bias. Epub 2008 Jun 4. … Interstitial Cystitis. Additionally, the variety of diagnostic methods and data sources used may have resulted in detection bias in some studies (Table S3). Risk ratios for developing uterine fibroids (UFs) by: (A) race and ethnicity in four registry studies; BJOG: An International Journal of Obstetrics & Gynaecology, International Journal of Gynecology & Obstetrics, Acta Obstetricia et Gynecologica Scandinavica, Australian and New Zealand Journal of Obstetrics and Gynaecology, Journal of Obstetrics and Gynaecology Research, I have read and accept the Wiley Online Library Terms and Conditions of Use, Smooth muscle, endometrial stromal, and mixed Mullerian tumors of the uterus, Uterine myomas in adolescents: case reports and a review of the literature, Uterine leiomyomata: etiology, symptomatology, and management, Uterine leiomyomas. Age, premenopausal state, hypertension, family history, time since last birth, and food additive and soybean milk consumption increased UF risk; use of oral contraceptives or the injectable contraceptive depot medroxyprogesterone acetate, smoking in women with low body mass index and parity reduced UF risk. medical record review, screening or self‐report) and the diagnostic method used (e.g. Nonetheless, uterine fibroids remain a common health burden, with a prevalence of nearly 10%. Estimated Prevalence and Incidence of Uterine Leiomyoma, and Its Treatment Trend in South Korean Women for 12 years: A National Population-Based Study. 2020 Dec 28;20(1):259. doi: 10.1186/s12905-020-01113-3. Lee SR, Lee ES, Lee YJ, Lee SW, Park JY, Kim DY, Kim SH, Kim YM, Suh DS, Kim YT. Association between vitamin D and uterine fibroids: a study protocol of an open-label, randomised controlled trial. Narasimman M, De Bedout V, Castillo DE, Miteva MI. Characteristics associated with prolonged length of stay after myomectomy for uterine fibroids. Martin CL, Huber LR, Thompson ME, Racine EF. Uterine leiomyomata, also known as fibroids, are the leading indication for hysterectomy in the United States. Quiz ; Uterine fibroid treatment trends: Take Quiz: Uterine fibroids: Etiology and epidemiology: Take Quiz: Evaluating uterine fibroids: Take Quiz: Understanding uterine fibroids: Take Quiz: Fast Facts Friday. Complementary Therapies in Clinical Practice. Ulipristal acetate for Japanese women with symptomatic uterine fibroids: A double‐blind, randomized, phase II dose‐finding study.  |  For consistency, one person made final decisions for screening the manuscripts and data extraction. If you do not receive an email within 10 minutes, your email address may not be registered, J Obstet Gynaecol Can. First described in 1793 by Matthew Baillie of St George's Hospital, London, uterine fibroids are the most common benign tumour in women, being clinically apparent in up to 25% of all women1 and up to 30–40% of women over 40 years of age. Owing to the heterogeneity of the data extracted (e.g. Journal of Obstetrics, Gynecology and Cancer Research. AU - Wise, Lauren A. American Journal of Obstetrics and Gynecology. Journal of Obstetrics and Gynaecology Research. BMI, body mass index; CI, confidence interval; DMPA, depot medroxyprogesterone acetate; IRR, incidence rate ratio; OR, odds ratio; RR, relative risk; UFs, uterine fibroids. In an Italian single‐centre study, women who currently used oral contraceptives were less than one‐third as likely to have UFs as those who had never used them (Table 1).78 Similar protective effects but of smaller magnitude were reported in the Nurses’ Health Study II, in which UF risk was 20% lower in all current oral contraceptive users and 53% lower in those with a history of 4–5 years’ oral contraceptive use than in women who had never used them,46 and in a multicentre case–control study in Thailand, in which UF risk was 24% lower in all women who had ever used oral contraceptives than in those who had never used them.77 In addition, women who had used the injectable contraceptive depot medroxyprogesterone acetate (DMPA) were less than half as likely to have UFs than those who had never used it (Table 1).77, Women with hypertension, defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg or current use of antihypertensive medication, had an almost fivefold increased risk of UFs compared with those with normal blood pressure in a Japanese single‐centre, case–control study (Table 1).80, In a large case–control survey conducted at a hospital in China, exposure to food additives in processed, sweetened or preserved foods increased the risk of UFs more than threefold compared with no exposure (Table 1).81 The same study found that women who consumed soybean milk had a 2.5‐times greater risk of UFs than those who did not (Table 1).81. Premenopausal state was associated with a significantly higher UF risk than postmenopausal state, reflecting the role of female gonadal steroid hormones in stimulating UF growth.26, 48, 75, 88 UFs may, however, be under‐reported by postmenopausal women because they do not experience menstruation‐associated symptoms. Preface. Risk factors, both modifiable and non-modifiable, are associated with the development of fibroids. T1 - Epidemiology of uterine fibroids. Long term effects of a first pregnancy on the hormonal environment: estrogens and androgens, Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki‐67 in leiomyoma and myometrium during the menstrual cycle and pregnancy. [ 1, 2] Despite the … Developing risk models for multicenter data using standard logistic regression produced suboptimal predictions: A simulation study. International Journal of Gynecology & Obstetrics. Uterine fibroids are the most commonly diagnosed uterine tumors, occurring in approximately 70% of all women (Stewart et al., 2017) African American women have a higher incidence of uterine fibroids, often reporting symptoms exacerbated symptoms and … Bayer AG provided funding for medical writing services to Oxford PharmaGenesis. Characterization of the role of Activator Protein 1 signaling pathway on extracellular matrix deposition in uterine leiomyoma. USA.gov. Quality of ultrasonography reporting and factors associated with selection of imaging modality for uterine fibroids in Canada: results from a prospective cohort registry. There was considerable diversity among the selected studies, including investigation type (e.g. Eleven other factors affected UF risk to a magnitude similar to or greater than race. Use of multiparametric MRI to characterize uterine fibroid tissue types. Given the hormonal dependence of fibroids, most earlier studies focused on reproductive or hormonal factors. Herein, we review the epidemiology of UL from published studies to date. European Journal of Obstetrics & Gynecology and Reproductive Biology. Pavone D, Clemenza S, Sorbi F, Fambrini M, Petraglia F. Best Pract Res Clin Obstet Gynaecol. There was a marked difference in UF incidence between racial groups, confirming that UFs are much more common in black than in white women (Figure 1B). Data collection and analysis: They are found in approximately 80% of hysterectomy specimens 2. Robot-Assisted Laparoscopic Myomectomy versus Abdominal Myomectomy for Large Myomas Sized over 10 cm or Weighing 250 g. and you may need to create a new Wiley Online Library account. National trends and determinants of hospitalization for uterine leiomyomas – Portuguese public database analysis from 2000 to 2015. African and Black Diaspora: An International Journal. Archives of Insect Biochemistry and Physiology. Assessing burden, risk factors, and perceived impact of uterine fibroids on women's lives in rural Haiti: implications for advancing a health equity agenda, a mixed methods study. The most common presenting symptom is heavy menstrual bleeding, which can lead to anaemia, and fatigue and painful periods.4-9 Other UF symptoms include non‐cyclic pain, abdominal protuberance, painful intercourse or pelvic pressure, and bladder or bowel dysfunction resulting in urinary incontinence or retention, pain or constipation.4-10 UFs may also be associated with reproductive problems, including impaired fertility, pregnancy complications and loss, and adverse obstetric outcomes.11-18 UFs are one of the leading causes of hospitalisations for gynaecological disorders, and are the most frequent reason for hysterectomy in the USA.19-24, Uterine fibroids are the most common neoplasm affecting women, and it has been postulated that they occur in over 70% of women by the onset of menopause.25-27 They are estimated to be clinically apparent in 25% of women of reproductive age and cause symptoms severe enough in approximately 25% of women with UFs to require treatment.4, 28, 29 The frequency of the condition is, however, likely to be underestimated because in many women it is asymptomatic, or symptoms develop insidiously, and therefore remains undiagnosed.30, 31 The unknown extent and impact of undetected UFs bias the epidemiological data and evidence on associated factors to reflect severe disease.32. We assessed the study and reporting quality of each study using the STROBE checklist,45 and also evaluated the risk of recall, selection and detection bias in each study. Nonhysteroscopic Myomectomy and Fertility Outcomes: A Systematic Review. To examine UF epidemiology and to evaluate the relative strengths of putative risk factors. Despite the prevalence and significant impact of fibroids, public awareness about the condition is extremely low. Full disclosure of interests available to view online as supporting information. Efficacy and safety of vilaprisan in women with uterine fibroids: Data from the phase 2b randomized controlled trial ASTEROID 2. The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids. N2 - Uterine leiomyomata (UL) have a substantial impactonwomen'shealth,butrelativelyfewstudieshave identified opportunities for primary prevention of these neoplasms. (A) Prevalence of uterine fibroids (UFs) in registry studies by follow‐up time. It may also be attributable to the role played by genetic factors in the development of UFs.82, 83, Smoking was found to reduce UF risk, but only in women with a low BMI, in one registry study.75 This may result from a putative anti‐estrogenic action of smoking, which may be counteracted in women with high BMI by the associated elevated estrogen levels.84-86 In addition, some women with low BMI may have hypothalamic dysfunction and associated chronic hypoestrogenism, which may compound any effect of smoking on estrogen activity.87. It should be noted, however, that 95% of the 95 061 women included in this study were white. 2018. Selection bias was present in most of the included studies, with study populations being randomly selected in only five studies. Publications reporting relevant data from registries and other observational studies with over 1000 patients and single‐centre studies with over 100 patients were selected. Data on the incidence of UFs reported in four large US registry studies (N, 9910–1 795 473; median, 42 098) ranged widely, from 217 cases per 100 000 women‐years in the California Teachers Study to 3745 cases per 100 000 women‐years in the Black Women's Health Study (Figure 1A).44, 48-70 The incidence reported from the Black Women's Health Study, in which all participants were black, was consistently higher than that in the California Teachers Study and the Nurses’ Health Study II (845–1348 cases per 100 000 women‐years), in which 3% and 1% of participants were black, respectively.44, 48-70 In the Nurses’ Health Study II, the incidence of UFs among Hispanic, Asian and white women was similar, but the incidence in black women was approximately three times higher than in the other populations (Figure 1B).44 This pattern was unchanged by the method of diagnosis of UF. Long-term follow-up outcome and reintervention analysis of ultrasound-guided high intensity focused ultrasound treatment for uterine fibroids. Journal of Gynecology Obstetrics and Human Reproduction. We identified 12 risk factors that play an important role in UF epidemiology. Age, premenopausal state, hypertension, family history, time since last birth, and food additive and soybean milk consumption increased UF risk; use of oral contraceptives or the injectable contraceptive depot medroxyprogesterone acetate, smoking in women with low body mass index and parity reduced UF risk. These include age, race, endogenous and exogenous hormonal factors, obesity, uterine infection, and lifestyle (diet, caffeine and alcohol consumption, physical activity, stress, and smoking). Hysterectomy studies and pregnancy studies were excluded from the analysis at this stage, because they are based on enriched populations that are subject to intensive clinical investigations (i.e. The quality of the epidemiological data varies widely between the studies reviewed, however. Uterine fibroid-related symptoms negatively impact physical and social activities, women's health-related quality of life, and work productivity. HHS Intra-abdominal haemorrhage from uterine fibroids: a systematic review of the literature. This site needs JavaScript to work properly. Although uterine leiomyomata (fibroids) have been the leading indication for hysterectomy in the United States for decades, the epidemiological data on fibroid prevalence and risk factors are limited. The multivariate‐adjusted RR or OR of UFs associated with black race compared with white race was reported in four registry studies. In addition, we have assessed the importance of the numerous risk factors that have been associated with the condition to identify the key factors that influence its occurrence. In all four studies, black women were found to have a two–threefold greater risk of developing UFs than white women (Figure 3A; Table 1);27, 44, 48, 54 the lower boundary of the 95% CI of the risk (black versus white) was 1.69 or higher in all four studies. Best Pract Res Clin Obstet Gynaecol. Steroid hormones and hormone antagonists regulate the neural marker neurotrimin in uterine leiomyoma. Serum micronutrient concentrations and risk of uterine fibroids. You can have a single fibroid or multiple ones. Epidemiology and Risk Factors of Uterine Myomas (Gloria D’Alessandro, MD, Fabio Barra, MD and Simone Ferrero, MD, PhD, Obstetrics and Gynecology, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy, and others) 2015 Feb ; 37 ( 2 ):157-178. doi: 10.1186/s12905-020-01113-3 glutamate-induced uterine hyperplasia in female type 2:157-178.... And costs worldwide differences in severity, symptoms and age at diagnosis, variety... ; 22 ( 4 ):176-181. doi: 10.1016/j.bpobgyn.2008.04.002 logistic regression produced suboptimal predictions: a case of Second-Trimester Fetal. With your friends and colleagues treatment, rehabilitation pathways in Pathophysiology of uterine fibroids are! Of UL from published studies to date study period ; study type ( e.g, M! D on uterine fibroids we review the epidemiology of UL from published studies to.! 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